Characteristics of Respiratory Syncytial Virus Infection in Hospitalized Children Before and During the COVID-19 Pandemic in Thailand.

OBJECTIVES: This study compared the epidemiological and clinical manifestations of patients hospitalized with respiratory syncytial virus (RSV) infection before and during the coronavirus disease 2019 (COVID-19) pandemic at a tertiary care hospital in Chiang Mai Province, Thailand. METHODS: This retrospective observational study utilized data from all cases of laboratory-confirmed RSV infection at Maharaj Nakorn Chiang Mai Hospital from January 2016 to December 2021. Differences in the clinical presentation of RSV infection before (2016 to 2019) and during (2020 to 2021) the COVID-19 pandemic were analyzed and compared. RESULTS: In total, 358 patients hospitalized with RSV infections were reported from January 2016 to December 2021. During the COVID-19 pandemic, only 74 cases of hospitalized RSV infection were reported. Compared to pre-pandemic levels, the clinical presentations of RSV infection showed statistically significant decreases in fever on admission (p=0.004), productive cough (p=0.004), sputum (p=0.003), nausea (p=0.03), cyanosis (p=0.004), pallor (p<0.001), diarrhea (p<0.001), and chest pain (p<0.001). Furthermore, vigilant measures to prevent the spread of COVID-19, including lockdowns, also interrupted the RSV season in Thailand from 2020 to 2021. CONCLUSIONS: The incidence of RSV infection was affected by the COVID-19 pandemic in Chiang Mai Province, Thailand, which also changed the clinical presentation and seasonal pattern of RSV infection in children.

Effects of wearing different facial masks on respiratory symptoms, oxygen saturation, and functional capacity during six-minute walk test in healthy subjects.

Background: During the current COVID-19 pandemic and increased air pollution levels, wearing a facial mask has been recommended. This study aimed to compare the impact of wearing different masks when performing a submaximal functional activity (six-minute walk test; 6MWT) on respiratory symptoms, oxygen saturation, and functional capacity. Methods: Twenty-nine subjects (10 men, 19 women; age 22 ± 1 yr.; FEV1/FVC 0.90 ± 0.01) performed four rounds of 6MWT wearing different masks (surgical (Medima SK, Thailand), handmade cloth, and N95 (3M AuraTM 1870+, USA)) and while not wearing a mask. Respiratory symptoms (dyspnea and breathing effort), oxygen saturation, and other physiological parameters were assessed before and after each walking trial. Results: Six-minute walking distances were comparable between walking trials (P = 0.59). At the end of minute 6, a significant difference between groups was found on dyspnea (P = 0.02) and breathing effort (P < 0.001). Post hoc tests showed that wearing a cloth mask significantly increased dyspnea (P = 0.004) compared to wearing a surgical mask. Wearing a cloth mask also significantly increased breathing effort compared to wearing a surgical mask (P < 0.001) and not wearing a mask (P < 0.001). Likewise, while wearing an N95 mask, breathing effort significantly increased compared to wearing a surgical mask (P = 0.007) and not wearing a mask (P = 0.002). Conclusions: Wearing different masks while performing submaximal functional activity results in no differences in functional performance, oxygen saturation, heart rate, or blood pressure. However, wearing cloth masks and N95 masks results in higher respiratory symptoms.